Searching for the “Holy Grail” of Alzheimer’s Treatments: BACE Inhibitors Free of Side-Effects

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

K Zhu, X Xiang, S Filser, P Marinković, MM Dorostkar, S Crux, U Neumann, DR Shimshek, G Rammes, C Haass, SF Lichtenthaler, JM Gunnersen, J Herms

2018-03-01

Background: Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promising drug target for the treatment of Alzheime..